Comparison of In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycle Outcome in Patients with and without Polycystic Ovary Syndrome: A Modified Poisson Regression Model

Authors

  • Amir Almasi-Hashiani Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  • Arezoo Esmailzadeh Department of obstetrics & gynecology, Zahedan University of Medical Sciences, Zahedan, Iran
  • Azadeh Ghaheri Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  • Mahdi Sepidarkish Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  • Mohammad Ali Mansournia Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences
  • Reza Omani Samani Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  • Samira Vesali Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abstract:

Objective Polycystic ovary syndrome is a frequent condition in women of reproductive age with prevalence rate of 5-10%. This study purposed to determine the relationship between polycystic ovary syndrome and the outcome of assisted reproductive treatment (ART) cycle in Tehran, Iran. MaterialsAndMethods In this historical cohort study, 996 infertile women were included in the study between January 2012 and December 2013. Polycystic ovary syndrome as a main variable and other potential confounder variables were gathered. Modified Poisson Regression was used to analyze the data. Stata software, version 13 was used for all statistical analyses. Results Unadjusted analysis showed that the risk of failure in polycystic ovary syndrome cases was significantly lower than whom did not have polycystic ovary syndrome (risk ratio: 0.79, 95% CI: 0.66-0.95, p=0.014). After adjusting for the confounder variables, there was no difference between risk of non pregnancy in women with and without polycystic ovary syndrome (risk ratio: 0.87, 95% CI: 0.72-1.05, p=0.15). The treatment protocol type, the number of embryo transferred grade A and AB, the number of injected ampoule, and age were the significant predictors of ART cycle outcome. Conclusion The results obtained from this model showed that no difference was found between patients with and without polycystic ovary syndrome according to the risk of non pregnancy. Therefore, other factors during may be effective to conceive patients with PCOs.

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Journal title

volume 11  issue 4

pages  309- 313

publication date 2018-10-01

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